The associations between prenatal and childhood exposure to pyrethroid incesticides and children’s behaviour were assessed in the PELAGIE mother-child cohort by Viel et al., 2017. Five pyrethroid metabolites (3-PBA, 4-F-3-PBA, cis-DCCA and trans-DCCA, and cis-DBCA) were measured in maternal and child urine samples and children’s behaviour was assessed using the Strengths and Difficulties Questionnaire (SDQ). It was shown that childhood 3-PBA concentrations were associated with externalising difficulties and increased prenatal cis-DCCA concentrations were associated with internalising difficulties. This study suggests that exposure to certain pyrethroids, even at environmental levels, during pregnancy and childhood, may affect the neurobehavioral development of children.

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